离体灌流肾技术检测缺血再灌注对大鼠肾功能和肾血管反应性的影响被引量：2

Effects of renal ischemia reperfusion on renal function and renal vascular responsibility in isolated perfused rat kidney

下载PDF

导出

摘要目的探讨肾缺血再灌注对大鼠肾功能和肾血管反应性的影响。方法应用离体灌流肾(IPK)技术观察肾缺血再灌注(IR)后大鼠IPK肾小球滤过率(GFR)、尿钠排泄指数(FENa)、肾血管阻力(RVR)和肾血管反应性的改变。结果(1)肾IR能够增大RVR、降低GFR,使尿钠排泄增多。(2)肾IR降低了IPK对NE和Ach的反应性。结论肾IR导致大鼠肾功能损伤和肾血管反应性降低。 Objective To investigate the effects of renal ischemia reperfusion on renal function and renal vascular responsibility in rats. Methods Isolated perfused kidney （IPK） was used to examine the effects of renal ischemia reperfusion on renal vascular resistance （RVR）, glomerular filtration rate （GFR）, fractional excretion of sodium （FENa） and renal vascular responsibility. Results （.1） renal ischemia reperfusion resulted in increase of RVR, decrease of GFR and increment of FENa（all P〈0.05）; （2）renal ischemia reperfusion decreased the renal vascular responsibility to NE and Ach. Conclusion Renal ischemia reperfusion can damage renal function and reduce renal vascular responsibility.

作者王新良李洪娟谢菲陈晓玲黄善生

机构地区河北医科大学第二医院儿科河北医科大学病理生理教研室

出处《新乡医学院学报》 CAS 2005年第5期441-443,共3页 Journal of Xinxiang Medical University

关键词肾缺血再灌注离体灌流肾肾功能肾血管反应性 Renal ischemia reperfusion isolated perfused kidney renal function renal vascular responsibility

分类号 R692.5 [医药卫生—泌尿科学]

引文网络
相关文献

参考文献11

1Lee HT, Ota-Setlik A, Fu Y, et al. Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo[J ]. Anesthesiology, 2004,101 (6): 1313-1324.
2Molina A, Ubeda M, Escribese MM, et al. Renal ischemia/reperfusion injury: functional tissue preservation by anti-activated β1 integrin therapy[J]. J Am Soc Nephrol, 2005 , 16(2): 374-382.
3Stephan D, Billing A, Krieger JP, et al. Endothelium-dependent relaxation in the isolated rat kidney: impairment by cyclosporine A[J].J Cardiovasc Pharmacol,1995, 26(6): 859-868.
4Espinoss G, Lopez Farre A, Cernadas MR, et al. Role of endothelin in the pathophysiology of renal ischemia-reperfusion in normal rabbits [J]. Kidney Int, 1996,50(3) :776-782.
5Rahgozar M, Willgoss DA, Gobe GC, et al. ATP-dependent K^+ channels in renal ischemia reperfusion injury [J ]. Ren Fail,2003,25 (6): 885-896.
6Cho EJ, Yokozawa T, Rhee SH, et al. The role of Coptidis Rhizoma extract in a renal ischemia-reperfusion model [ J ]. Phytomedicine ,2004, 11(7-8) :576-584.
7Jeong GY, Chung KY,Lee WJ, et al. The effect of a nitric oxide donor on endogenous endothelin-1 expression in renal ischemia/reperfusion injury [ J ]. Transplant Proc, 2004, 36 ( 7 ): 1943-1945.
8Bojakowski K, Abramczyk P, Bojakowska M, et al. Fucoidan improves the renal blood flow in the early stage of renal ischemia/reperfusion injury in the rat [J ]. J Physiol Pharmacol,2001 ,52(1): 137-143.
9de Vries PA, Navis G, de Jong PE, et al. Impaired renal vascular response to a D1-like receptor agonist but not to an ACE inhibitor in conscious spontaneously hypertensive rats [J ]. J Cardiovasc Pharmacol, 1999, 34(2): 191-198.
10Malmstrom RE, Lundberg JM. Time-dependent effects of ischaemia on neuropeptide Y mechanisms in pig renal vascular control in vivo[J].Acta Physiol Scand, 1997, 161(3): 327-338.