流感疫苗免疫效果评估

Observation on Immune Efficacy of Influenza Vaccine

目的评估接种流感疫苗后对人群的免疫效果.方法随机选择不同年龄组的志愿者,按照流感疫苗使用说明书的要求接种,接种前和接种后20 d,分别对观察者体内甲1(A1)、甲3(A3)和乙(B)型抗体进行检测,比较观察免疫前后志愿者体内各亚型流感抗体效价、阳转率及保护率.结果接种前后各年龄组各亚型的流感抗体效价有显著性差异,平均GMT从免疫前的1 :14.45上升至免疫后的1:233.6;阳转率为71.9%～96.6%;抗体保护率从免疫前的0.023%～52%上升至免疫后的83%～100%.结论流感疫苗无论是国产的还是进口的,流感疫苗毒株抗原与湖北省流行流感毒株的抗原是相匹配的,可用于湖北省流感流行的控制.

Objective To evaluate the efficacy of influenza vaccine. Methods Volunteers of different ages were randomly selected and vaccinated accordingto the instruction of the influenza vaccine guideline. The antibody levels（GMT）,positive and protective rate were compared before and after vaccination. Results The antibody levels in each tested age group was significantly different before and after vaccination, the average GMT increased from 1 ： 14.45 before vaccination to 1 ： 233.6 after vaccination; 71.9%-96.6% positive rate and 83%-100% was obtained against A1,A3 and B influenza after vaccination. Conclusion The influenza vaccine showed satisfactory immune efficacy and could be used for influenza control in Hubei.