p53 codon72基因多态性与宫颈癌发病风险的meta分析

A meta-analysis of p53 codon72 polymorphism and the risk for cervical cancer

目的利用meta分析的方法系统评价p53 codon72多态性与宫颈癌发病风险的关系.方法检索1998～2004年Medline、Elsevier、Evidence-Based Medicine Reviews、Ovid、中国期刊网、维普科技期刊数据库等,语种不限.并追溯检索获得的已发表文献及我们研究组未发表的文献.纳入标准:涉及p53 codon72基因型频率的独立病例对照研究,各文献研究方法相似,有综合的统计指标.剔除不符合纳入标准的,重复研究报告及数据不完整的文献.用RevMan4.2软件进行统计分析.结果将总研究按病理组织学类型及种族和地域进行亚组分析,亚洲人群宫颈上皮内瘤样变(CIN)亚组和欧洲人群(主要为白种人)CIN亚组分析显示与其对照组无统计学差异.亚洲人群宫颈鳞癌(SCC)亚组合并OR=1.28,95% CI=1.05～1.55.欧洲人群SCC亚组合并OR=1.45,95% CI=1.08～1.95,P<0.01,有统计学意义.结论 p53 codon72 Arg/Arg基因型未能增加亚洲人群和欧洲人群宫颈癌前期病变发生的危险性,但与浸润性宫颈癌发病风险有正向弱相关性.

Objective To evaluate relationship between p53 codon72 polymorphism and cervical cancer（CC） by using meta-analysis. Methods Studies from 1998 to 2004 were retrieved through Medline, Elsevier, EBMR, Ovid, CNKI and VIP databases without language limitation. The unpublished data of our study was also included, The inclusion criteria of studies were： ① case-control studies associated with p53 codon72 genotype/allele frequencies and CC. ② CC as the outcome of interest. ③ the risk for CC had odds ratio or enough information to calculate it. RevMan4.2 software was applied to process data. Results All studies were analyzed as subgroups according to pathologic histology and race/region. The outcome of CIN of Asia and European population subgroups showed no statistically difference with the control groups. However, in ICC subgroups the frequencies of Arg/Arg genotype were significantly higher than that in the control group（Z=2.43, P=0.01, OR= 1.28; Z=2.44, P：0.01, OR= 1. 45）. Conclusion This study suggests that polymorphism at codon72 of p53 gene is not associated with an increased susceptibility to CIN. However, a slightly increased risk was observed for ICC of Asian and European population subgroups. A possible susceptibility role of p53 codon72 polymorphism at a late carcinogenetic stage of cervical cancer cannot be ruled out.