自体游离骨膜移植修复髁突软骨缺损的实验研究

ReconstructionofTMJcondylecartilagedefectswithautogenousfreeperiostealgrafts

治疗各种关节病的关键问题是软骨层的修复。颞下颌关节紊乱综合征、创伤、炎症及手术等导致的器质性髁突软骨破坏的病例很多，为了寻找髁突软骨缺损修复更有效的方法，本实验将家兔的一侧关节髁突造成４ｍｍ×５ｍｍ大小的全层软骨缺损，用自体游离骨膜移植于软骨缺损区，术后分别于１、２、４、８、１２和１６周处死动物，对缺损区的新生软骨组织进行大体和组织学观察。结果显示，游离骨膜移植修复髁突软骨缺损，在关节局部的应力作用下可以成活并化生成软骨组织，其组织结构接近正常关节软骨。

Howtoreconstructthedamagedarticularcartilagehasbenoneofthemainsubjectsintreatmentofarticulardiseaseforalongtime.Inthisexperimentalstudy,fulthicknesscartilagedefectsof4mm×5mminsizewerecreatedinrabbit′sTMJcondylecartiageontheleftsides.Theau-togenousfrepertiosteumweretransplantedtothedefectsbyusingbiologicalgelatin.Postoperativ-ely,theanimalswerekiledatintervalsof1,2,4,8,12and16weeks.Theregenerativecartilageinthedefectswereexaminedbygrosappearanceandhistology.Theresultshowedthatmesenchymalcelsinthecambiumlayerofperiostumcantransformintochondroblastsunderthemechanicalstress.