前哨淋巴结活检在口腔鳞状细胞癌治疗中的临床意义

Clinical application of sentinel lymph node biopsy for treatment of oral squamous cell cacinoma

目的探讨前哨淋巴结活检(sentinellymphnodebiopsy,SLNB)在口腔鳞状细胞癌临床应用中的可行性、准确性。方法对31例口腔鳞状细胞癌患者术前使用核素扫描法行前哨淋巴结(sentinellymphnode,SLN)示踪,体表定位;术中γ-探测仪进一步识别SLN行前哨淋巴结活检,同时行颈淋巴清扫;术后对SLN和颈淋巴清扫的病理检查结果进行分析。结果SLNB对全组病例颈部淋巴结转移状况评价的准确率为96.8%,灵敏度为92.3%,假阴性率为7.7%。结论SLNB是口腔鳞状细胞癌治疗中的一项新技术,能高灵敏度的反映颈淋巴结状态,具有临床可实用性。

Objective To assess the feasibility and accuracy of sentinel lymph node biopsy （SLNB） in diagnosis of treatment of oral sqnamous cell carcinoma （OSCC）. Methods Thirty patients with the SLN were identified by lymphoscintigraphy before the operation and labeled on skin of body. In the surgery, the SLN were detected and SLNB were performed using the hand - held gamma probe before the neck dissection, After the surgery, all the sentinel and nonsentinel lymph nodes were sent for histological examination and the results were analyzed. Results In this study, the accuracy of SLNB diagnosis or treatment？ was 96, 8% ; the sensitivity was 92.3% and the false negative was 7. 7%. Conclusion SLNB is a new technique with high accuracy for the treatment of OSCC.