冠心病中医证型与血浆ET、TXA_2-PGI_2的关系

The Relationship between the Syndromes of TCM and ET and TXA_2-PGI_2 of Blood Plasma of Coronary Heart Disease

目的:探讨冠心病患者中医证型与血浆ET、TXA2-PGI2平衡系统的关系。方法:对56例冠心病患者按两种不同中医辨证分型方法,观察各证型组的血浆ET、TXB2、6-K-PGF1a的含量及TXB2/6-K-PGF1a比值,并与30例健康者作对照比较。结果:痰浊组ET水平显著升高,痰浊组、气虚挟淤组、血淤组ET、TXB2、6-K-PGF1a、TXB2/6-K-PGF1a水平均显著升高,阴虚组、气阴两虚组、血淤组6-K-PGF1a水平显著降低。结论:血浆ET、TXB2、6-K-PGF1a、TXB2/6-K-PGF1a可以作为冠心病中医证型的有效客观指标。

Objective：To investigate the changes of endothelin （ET） ,Thromboxame A2 - Prostaglandins （TXA2 -PGI2 ） in different TCM Type of Coronary Heart Disease Patients （CHD）. Methods： Plasma ET,TXB2 ,6-K-PGF1a were measured in 56patients with CHD and normal subjects. Result：The level of ET in the groups of the retention of phlegm - turbid and bolld stasis syndrome was sinificantly increased. The level of ET,TXB2 ,TXB2/6-K-PGF1a in the groups of the retention of phlegm- turbid, Qi deficiency with bolld stasis syndrome,blood stasis syndrome were sinificantly increased. The level of 6-K-PGF1a in the groups of Yin deficiency,defi- ciency of both Qi and Yin, blood stasis syndrome were sinificantly lower. Conclusions ：The level of ET,TXB2 ,6-K-PGF1a ,TXB/6-K-PGF1a in patients with CHD were associated with Syndrome - Type.