新型阴离子型温敏水凝胶

Novel Anionic Thermosensitive Hydrogels

新型阴离子型温敏水凝胶王昌华，曹维孝（北京大学化学与分子工程学院，北京，１００８７１）关键词温敏水凝胶，溶胀比，Ｎ－异丙基丙烯酰胺１９８４年Ｔａｎａｋａ等人［１］发现Ｎ－异丙基丙烯酰胺（ＮＩＰＡ）与Ｎ，Ｎ－亚甲基双丙烯酰胺（ＭＢＡ）的微交联共聚体，在...

Novel anionic thermosensitive hydrogels were prepared by the copolymerization of N-isopropyl acrylamide(NIPA) with 3-sulfopropyl acrylate potassium salt(SPAP) as anionic monomer in the presence of methylene-bisacrylamide(MBA).The hydrogels exhibit excellent thermosensitive behavior and high swelling properites,In the feed ratios varing from 1.0% to 2.0%(molar ratio) SPAP content the hydrogels possess the volume ratios of 27～38 and the sensitive temperatures varied from 35℃ to 38℃,which are very close to the human body temperature,and very important for Drug Delivery Systems(DDS).