奥沙利铂加醛氢叶酸和大剂量氟尿嘧啶治疗晚期大肠癌

Clinical study of oxaliplatin plus LV and high dosage of 5-Fu for treating colorectal carcinoma

目的:观察奥沙利铂加醛氢叶酸(LV)和大剂量氟尿嘧啶(5Fu)持续48小时滴注(双周疗法)治疗大肠癌的疗效和毒性。方法:31例晚期大肠癌患者,均为术后有残留病灶或复发转移不能切除的有可测量病灶的患者,静脉滴注奥沙利铂100mg/m2,LV200mg/m2,LV滴注之后用5Fu0.5g静推,接着用5Fu3.0g/m2持续48小时静脉滴注,2周重复,4周为周期。结果:31例可测量实体病灶的患者,平均疗程数为3.62个,其中CR2例,PR14例,SD11例和PD4例,近期有效率(CR+PR)为51.6%。结论:奥沙利铂加LV/5Fu方案疗效高,毒副作用小,患者容易耐受,值得推广使用。

Objective：To survey the clinical efficacy and toxicity of Oxaliplatin plus LV and high dosage of 5-Fu continuous infusion 48 hours（ therapy of double cycles） in treatment of the patients of colorectal carcinomas. Methods：31 patients with colorectal carcinomas of having rudimental focuses or impossibly ablated recrudescent metastases which could be measured. Drip-injecting Oxaliplatin 100mg/m^2 ,LV 200mg/m^2 and after dripping LV,5-Fu 0. 5g into vein followed by dripping 5-Fu 3. 0g/m^2 into vein lasting 48 hours were performed that were repeated per two weeks. Every four weeks was a cycle. Results：In 31 patients with measurable estimatire focuses who were experienced 3.62 periods of treatment averagely,2 patients were in CR, 14 ones were in PR, 11 ones were in SD. The effective rate in near time（ CR ＋ PR） was 51.6%. Conclusion：The regimen of oxaliplatin plus LV and high dosage of 5-Fu is effective and safe. It is deserved to be spreaded and applicated.