低分子质量肝素治疗不稳定型心绞痛的效果

EFFECT OF LOW MOLECULAR WEIGHT HEPARIN ON UNSTABLE ANGINA PECTORIS

①目的探讨低分子质量肝素(LMWH)治疗不稳定型心绞痛(UAP)效果.②方法将60例新近发生的UAP病人随机分为两组:治疗组(30例)给予皮下注射LMWH(0.4 mL,每12 h 1次,连续7 d),加阿司匹林和抗心绞痛药物治疗;对照组(30例)只给予阿司匹林和抗心绞痛药物治疗.观察并比较两组治疗结果.③结果治疗组有效率为96.7%,对照组为80.0%,两组疗效比较,差异有显著性(uc=2.92,P＜0.01).治疗组治疗后心绞痛发作频率、硝酸甘油用量与对照组比较明显减少,差异有显著性(t=13.93、22.42,P＜0.01).治疗组仅1例发生皮下淤斑.两组治疗前后血小板计数、凝血酶原时间及激活的部分凝血酶原时间差异无显著性(t=1.73～1.91,P＞0.05).④结论UAP病人急性期应用LMWH治疗,安全、有效和便利.

Objective To determine the therapeutic effectiveness of low molecular weight heparin （LMWH） in the treatment of unstable angina pectoris （UAP）. Methods A total of 60 patients with recent UAP were randomly divided into two groups. The 30 patients in the treatment group were given antianginal agents plus aspirin （300 mg/d） and LMWH （0.4 mL,twice daily subcutaneously） ; those in the control group received antianginal plus asprin. Results The effective rate of the treatment group and the control group was 96.7% and 80.0%, respectively （uc =2.92 ,P〈0. 01）. After the treatment, the frequency of angina pectoris and quantity of glycerol trinitrate in the treatment group were less than in the control group （t= 13.93,22.42; P〈 0.01）. The PLT, PT and APTT were not significantly different between the two groups （t= 1.73- 1.91; P〉0.05）. Conclusion LMWH is efficient ,safe and convenient in the treatment of UAP in acute stage.