冠心病患者血清氧化修饰低密度脂蛋白抗体和可溶性细胞间黏附分子相关性研究

Relativity of Autoantibody Titers to Oxidized Low-density Lipoprotein and Intracellular Cell Adhesion Molecule-1 in Patients with Coronary Atherosclerosis

目的:探讨脂质氧化沉积和内皮损伤在动脉粥样硬化(AS)形成中的相互作用。方法:检测38例心绞痛患者、24例急性心肌梗死患者和20例正常人血清中氧化修饰低密度脂蛋白抗体(OX-LDL-Ab)滴度和可溶性细胞间黏附分子-1(sICAM-1)水平以及它们之间的相关性。结果:冠心病患者血清中OX-LDL-Ab滴度明显高于正常对照组,其中心肌梗死患者血清中最高。OX-LDL-Ab与sICAM-1呈正相关。结论:冠心病患者体内低密度脂蛋白(LDL)氧化修饰和内皮损伤增加,二者有相互促进作用。

Objective ： This study was to determine the multiple interaction of injuries of endothelial cell and deposition of oxidized lipoprotein in atherosclerosis. Methods： Serum autoantibody to oxidized low-density lipoprotein（OX-LDL-Ab） titres and intracellular cell adhesion molecule-1 （ slCAM-1 ） amount were measured by ELISA method and the relativity of them were analyzed in 38 cases of angina, 24 cases of myo- cardiol infarction and 20 cases of control. Results ： OX-LDL-Ab titres and slCAM-1 amount in patients with coronary artery disease, esplicially in patients with myocardiol infarction, were obviously higher than that in serum of control group. OX-LDL-Ab titres positively correlated with slCAM-1 amount. Conclusion： Injuries of endothelial cell and deposition of oxidized lipoprotein can accelerate each other.