摘要
近年来,有关足细胞损伤与糖尿病肾病的研究取得了较大的进展,足细胞损伤是糖尿病肾病发生、发展的一个重要环节。本文对糖尿病肾病足细胞损伤的原因、病变特点以及与糖尿病肾病的关系和糖尿病肾病足细胞损伤的防治作一综述。
出处
《国外医学(泌尿系统分册)》
2005年第5期680-684,共5页
Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
参考文献27
-
1刘志红,李世军,陈朝红,曾彩虹,张波,周虹,黎磊石.糖尿病肾病患者足细胞病变的临床病理特征[J].肾脏病与透析肾移植杂志,2003,12(2):144-148. 被引量:67
-
2Petermann AT, Pippin J, Blonski M, et al. Viable podocytes detach in experimental diabetic nephropathy:potential mechanism underlying glomerulosclerosis. Nephron Exp Nephrol,2004,98(4): e114 - 23.
-
3White KE, Bilous RW. Structural alterations to the podocytes are related to proteinuria in type 2 diabetic patients. Nephol Dial Transplant,2004,19(6): 1437 - 40.
-
4Dalla Vestra M, Masiero A, Roiter AM, et al. Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes,2003,52(4): 1031 - 5.
-
5White KE,Bilous RW,Marshall SM,et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes, 2002, 51 (10):3083 - 9.
-
6Nakamura T, Ushiyama C, Suzuki S, et al. Urinary excretion of podocytes in patients with diabetic nephropathy. Nephol Dial Transplant, 2000, 15(9): 1379 - 83.
-
7Forbes JM, Bonnet F, Russo LM, et al. Modilation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria. J Hypertens,2002,20(5) :985 - 992.
-
8]Aaltonen P, Luimula P, Astrom E, et al. Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy. Lab Invest, 2001,81(9), 1185 - 90.
-
9Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin Ⅱ. Diabeties,2003,52(4):1023- 1030.
-
10Pettersson- Femholm K,Forsblorn C,Perola M,et al. Polymorphisms in the nephrin gene and diabetic nephropathy in type 1 diabetic. Kidney Int,2003,63(4) :1205 - 10.
二级参考文献14
-
1Hoshi S, Shu Y, Yoshida F et al. Podocyte injury promotes progressive nephropathy in Zucker diabetic fatty rats. Lab Invest,2002,82:25.
-
2Tryggvason K, Wartiovaara J. Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens,2001,10:543.
-
3Endlich K, Kriz W, Wltzgall R. Update in podocyte biology. Curr Opin Nephrol Hypertens,2001,10:331.
-
4Mundel P, Shazkland S J. Podocyte biology and response to injury. J Am Soc Nephrol,2002,13:3005.
-
5Steffes MW, Schmidt D, McCrery R et al. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int, 2001,59:2104.
-
6Pagtaluma ME, Miller PL, Jamping-Eagle S et al. Podocyte loss and progressive glomerular injury in type Ⅱ diabetes. J Clin Invest, 1997,90:342.
-
7Lemley KV, Blouch K, Abdullah I et al. Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus. J Am Soc Nephrol,2000,11:2095.
-
8Cruz MCI, ZiYadeh FN, Isono M et al. Effects of high glucose and TGF-β1 on the expression of collagen Ⅳ and vascular endothelial growth factor in mouse podocytes. Kidney Int,2002,62:901.
-
9White K E, Bilous R W, Marshall S M et al.Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes,2002,51:3083.
-
10nakamura T,UshiYama C,Suzuki S et al. Urinary excretion of podocytes in patients with diabetic nephropathy.Nephrol Dial Transplant, 2000,15:1379.
共引文献66
-
1李栋,林珊,贾俊亚,郑振峰,贾忠辉,商文雅.螺内酯对1型糖尿病大鼠足细胞黏附功能的保护作用[J].中华糖尿病杂志,2009,1(4). 被引量:1
-
2杨琪,周柱亮,汪建国,马路,潘涛,周敏.肾小球足细胞synaptopodin和WT-1表达水平与糖尿病肾病患者肾脏损害的关系[J].中华糖尿病杂志,2010,2(2). 被引量:5
-
3陈淑娇,郑京.ACEI、ARB阻止糖尿病肾病发展的机制[J].现代实用医学,2004,16(12):740-742. 被引量:16
-
4李瑛,刘志红,郭啸华,苏健,黎磊石.马兜铃酸Ⅰ致肾小管上皮细胞DNA损伤的逆转性实验[J].肾脏病与透析肾移植杂志,2005,14(2):101-104. 被引量:6
-
5苏健,陈惠萍.尿沉渣检查在肾脏疾病诊断和治疗中的应用[J].肾脏病与透析肾移植杂志,2005,14(2):169-173. 被引量:9
-
6陈慧梅,刘志红,苏健,曾彩虹,李世军,黎磊石.肥胖相关性肾病患者的足细胞损伤[J].肾脏病与透析肾移植杂志,2005,14(4):306-312. 被引量:9
-
7李佑生,王文健.中医药防治糖尿病肾病的机制研究述评[J].上海中医药杂志,2005,39(10):56-59. 被引量:20
-
8陈慧梅,刘志红,杨斌,蔡军,陈燕,王庆文,黎磊石.肥胖患者体脂分布与肾脏损害的关系[J].肾脏病与透析肾移植杂志,2006,15(2):120-126. 被引量:6
-
9刘志红.糖尿病肾病:深入研究,全面认识,推进临床[J].中华肾脏病杂志,2006,22(9):519-520. 被引量:37
-
10王艳,马瑞霞,栾健,翟丽慧.糖尿病肾病大鼠血管内皮细胞生长因子及其受体表达与厄贝沙坦的干预效应[J].中国组织工程研究与临床康复,2007,11(10):1845-1849.
同被引文献24
-
1秦卫松,刘志红.雷公藤甲素及其作用机制[J].肾脏病与透析肾移植杂志,2007,16(2):158-161. 被引量:21
-
2Romosan I, Caraba A, Golea O. The etiology of proteinuria in diabetic patients[J]. Med Pregl, 2007,60 (2):74-77.
-
3Ziyadeh FN, Wolf G. Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy[J]. Curt Diabetes Rev, 2008, 4(1) :39-45.
-
4Croom KF, Plosker GL. Irbesartan: a review of its use in hypertension and diabetic nephropathy[J]. Drugs, 2008,68 (11) : 1543- 69.
-
5Luimula P,Ahola H,Wang SX,et al.Nephrin in experimental glomerular disease[J].Kidney Int,2000,58(4):1461.
-
6Furness PN,Hall L,Shaw JA,et al.Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome[J]. Nephrol Dial Transplant, 1999, 14(5):1234.
-
7White KE,Bilous RW.Diabiopsies Study Group.Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients[J]. Nephrol Dial Transplant,2004,19(6):1437.
-
8Camussi G,Mariano F,Biancone L,et al.Effect of cytokines on the cytoskeleton of resident glomerular cells[J].Kidney Int,1993,39(Supp1):32-36.
-
9Garg P,Verma R,Holzman LB.Slit diaphragm junctional complex and regulation of the cytoskeleton[J].Nephron Exp Nephrol,2007,106(2):e67-e72.
-
10Ichimura K,Kurihara H,Sakai T.Actin filament organization of foot processes in vertebrate glomerular podocytes[J].Cell Tissue Res,2007,329(3):541-557.
引证文献2
-
1郝丽,潘梦舒,郑云,王瑞峰.冬虫夏草及雷公藤多甙对糖尿病肾病大鼠足细胞影响的实验研究[J].中国中西医结合杂志,2012,32(2):261-265. 被引量:25
-
2杨岳,谢席胜,冯胜刚,左川,李孜,樊均明.厄贝沙坦对糖尿病大鼠肾脏足细胞保护作用的研究[J].西部医学,2012,24(2):214-217. 被引量:8
二级引证文献33
-
1朱荣宽,李靖.糖尿病肾病与Nephrin蛋白[J].中国医药指南,2012,10(23):109-110. 被引量:2
-
2张勇军,孙永苹,刘冬.雷公藤多苷和厄贝沙坦治疗2型糖尿病肾病的效果观察[J].中国医药导报,2012,9(34):73-74. 被引量:6
-
3肖舟,陈晨,李晓照,刘抗寒,袁明霞,包瑞南,周巧玲.冬虫夏草抑制ET-1对糖尿病肾病大鼠肾小管上皮细胞转分化作用[J].中国中西医结合肾病杂志,2012,13(12):1082-1085. 被引量:11
-
4张勇军,刘冬,孙永苹,莫镇涛.雷公藤多甙对糖尿病大鼠尿蛋白、肾小球硬化及足细胞的影响[J].新医学,2013,44(7):504-507. 被引量:6
-
5陈薇薇.雷公藤多苷联合中等剂量强的松治疗老年原发性肾病综合征的疗效观察[J].世界中西医结合杂志,2013,8(10):1031-1033. 被引量:10
-
6刘乃琴,邵卉,赵香芳,常连庆.冬虫夏草肾保护的分子生物学机制研究进展[J].医学综述,2014,20(1):123-126. 被引量:3
-
7姚风良,陈洪宇.冬虫夏草及其制剂治疗慢性肾病的研究及进展[J].浙江中医药大学学报,2014,38(2):230-232. 被引量:8
-
8何慧群,魏建红.治疗饮食干预方式在糖尿病肾病治疗中的临床效果观察[J].中国中西医结合肾病杂志,2014,15(3):252-253. 被引量:3
-
9高俊丽,朱赟洁,王巍巍,张金元.中医辨治糖尿病肾病的研究进展[J].四川中医,2019,37(1):216-221. 被引量:36
-
10郭呈林,方朝晖.糖尿病肾病中医药治疗现状[J].中医药临床杂志,2014,26(6):643-645. 被引量:2
-
1陈铿(综述),刘华锋(审校),陈孝文(审校).足细胞损伤与蛋白尿足细胞损伤与蛋白尿[J].国际泌尿系统杂志,2008,28(1):140-144.
-
2唐英,蒋宇锋,邹赟,张昕贤,何立群.IgA肾病足细胞损伤机制及中医药治疗的研究进展[J].中国中西医结合肾病杂志,2016,17(8):744-746. 被引量:4
-
3姜文玲(综述),彭佑铭(综述),刘虹(综述).足细胞损伤与IgA肾病[J].国际泌尿系统杂志,2009,29(5):704-708. 被引量:2
-
4李振勇,倪兆慧.足细胞损伤的干预研究进展[J].国际泌尿系统杂志,2006,26(4):547-550. 被引量:4
-
5向少伟(综述),王小琴(审校).转化生长因子-β1介导的足细胞损伤[J].国际泌尿系统杂志,2008,28(4):559-563. 被引量:1
-
6宁政.肺挫伤的CT诊断附52例分析[J].中国实用医药,2011,6(3):59-59. 被引量:2
-
7陈科,王书成,卢传新,陈膺镇.老年人腰椎间盘突出症[J].海南医学,1996,7(3):164-165.
-
8王铁维.胆源性急性胰腺炎临床治疗分析[J].中国实用医药,2010,5(4):102-102.
-
9西永明,胡有谷.椎间盘退变动物模型病变特点的研究进展[J].齐鲁医学杂志,2000,15(2):152-154.
-
10孙景成.肩周炎的症状有哪些[J].长寿,2002,0(7):14-14.