摘要
缺氧前、后分别给7日龄Wistar新生大鼠HIE模型腹腔注射丹参注射液,4周后处死。结果显示:预防组用药效果显著,能使脑萎缩、软化、液化等形态学病变发生率由对照组的92.31%降到38.01%(P<0.05),脑萎缩程度明显减轻(P<0.001),眼和/或视神经萎缩发生率由100%降到66.67%(P<0.05),治疗也能明显减轻脑萎缩程度(P<0.05)。
The salivia militirrhizae injection was given intraperitoneally to 7-day-old Wistar newborn rats before or after the hypoxic-ischemic insults according to different schedules,and 4 weeks later the rats were killed.The results demonstrated that in comparison with the control group,in prevention group the incidence rates of cerebral atrophy, softening and liquifaction etc. were greatly reduced from 92.31% to 38.01%(P<0. 05),the extent of cerebral atrophy was significantly reduced (P<0.001), and the incidence rate for eye/visual nerve was reduced from 100% to 66. 67% (P<0.05).The extent of cerebral atrophy was also significantly reduced in the treatment group(P<0.05).
出处
《北京医学》
CAS
北大核心
1996年第1期14-16,共3页
Beijing Medical Journal
关键词
缺氧缺血性脑病
新生儿
大鼠
丹参
疗效
Newborn rat
Hypoxic-ischemic encephalopathy
Salivia militirrhizae