奥扎格雷钠对脑梗塞及血流动力学、血凝的影响

Effect of Ozagrel Sodiumon Hemodynamics and Blood Coagulation in Pati ents with Cerebral Infarction

目的:研究奥扎格雷钠治疗脑梗塞的疗效及其对血流动力学、血凝及纤溶系统的影响。方法:选择脑梗塞患者80例,随机分为两组,治疗组40例,奥扎格雷注射液160mg,静脉注射,1次/d,14天;对照组40例,丹参注射液40ml加七叶皂甙钠20mg,静脉注射,1次/d,14天。治疗前后两组病例分别进行神经功能缺损评分(改良爱丁堡斯堪的纳维亚评分SSS评分)、血尿便常规、血小板计数、血流动力学、血凝分析、肝肾功能、大便隐血等指标检测。并观察不良反应。结果:治疗组疗效明显优于对照组(χ2=8.596,P<0.05),血液粘度、红细胞压积、红细胞聚集指数明显下降(P<0.05,0.01);PT、APTT、TT延长,PA、FbG降低;(P<0.05);无明显不良反应。结论:奥扎格雷钠注射液可降低血液粘度、改善血流动力学,可延长PT、APTT、TT,降低PA、FbG,安全可靠,是一种治疗脑梗塞及其他缺血性脑血管病的新型理想药物。

Objective：To study effects of the ozagrel sodium injection on hemodynamics and coagulation in patients with cerebral infarction. Methods： 80 patients with cerebral infarction were randomly divided into ozagrel group （40 casses）in which ozagrel sodium was given 160mg,iv,once daily for 14 days, and danshen group（40 class）in which danshen was given 40ml, iv, once daily for 14 days. The blood, urine and stool routine, platelet count , changes of hemodynamics and coagulation were respectively examined. Results：The treatment effect of ozagrel group was better than the danshen group （P〈0. 05 or 0. 01） in cerebral infarction. Conclusious：The ozagrel sodium is an effective drug in treatment of cerebral infarction.