急性缺血性卒中的神经保护药物研究进展

Recent progress in research of neuroprotective drugs on acute ischemic stroke

缺血性脑损伤的病理生理机制包括兴奋性氨基酸的释放、梗死灶周围去极化、炎症反应及神经元凋亡等。几乎对缺血级联反应的所有环节都已进行过神经保护药物的开发和试验。许多神经保护药物在脑缺血动物模型研究中证明有效,但临床试验效果却难以令人满意。本文就目前各类神经保护药治疗脑缺血的临床前期和临床试验的结果与进展作简要的回顾和展望。

The pathophysiological mechanisms of isehemic cerehral injury, involved in the release of excitatory amino acids, depolarization about the infarction, inflammatory reaction and neuron apoptosis. The development and trial of neuroproteetive drugs have almost been launched in all links of ischemic cascade reaction. Many neuroprotective drugs were proved to be effective for cerebral ischemia in animal models, but they were not provedon clinical trials. The results and progresses of the preclinical phase and clinical application of various kinds of neuroprotective drugs on the cerebral ischemia were reviewed in this paper and the prospective uses of these drugs were also introduced.