猪牙皂正丁醇部分对过敏性鼻炎的影响

Inhibition of allergic rhinitis by n-butanol fraction from anomalous fruits of Gleditsia sinensis

目的:观察猪牙皂正丁醇部分(NBGS)对过敏性鼻炎的治疗作用,探讨其可能的作用机制。方法:以卵白蛋白致敏小鼠或大鼠,观察药物对小鼠鼻炎症状、鼻腔敏感性和血清一氧化氮水平的影响,以及对大鼠鼻腔白细胞渗出的作用。结果:NBGS(100,200mg·kg-1)灌胃给药,明显减少小鼠的擦鼻次数,降低鼻粘膜对组胺的敏感性和血清一氧化氮水平,抑制大鼠鼻腔嗜酸性粒细胞渗出,但对单核细胞和嗜中性粒细胞渗出无明显影响。结论:NBGS抑制过敏性鼻炎,其作用可能与降低鼻粘膜的高反应性及嗜酸性粒细胞浸润有关。

AIM： To investigate the effects of the Nbutanol fraction from the anomalous fi＇uits of Gleditsia sinensis （NBGS） on allergic rhinitis, and to explore the underlying mechanism of action. METHODS： In sensitized mice with ovalbumin, effects of NBGS on rhinitis symptoms, nasal histamine responsiveness and serum levels of nitric oxide were studied. In sensitized rats, effect of NBGS on the numbers of differential lcukocytes in nasal cavity lavage fluid was observed. RESULTS： NBGS （100, 200 mg·kg^-1, p. o. ） effectivelv reduced nasalwiping times, nasal hyperresponsiveness and serum levels of nitric oxide in sensitized mice. NBGS also restrained eosinophil effusion of nasal cavity in sensitized rats, but it did not affect the effusion of monocytes and neutrophils. CONCLUSION： NBGS is effective in alleviating the nasal symptoms of allergic rhinitis, which is probably contributed by lowing nasal hyperresponsiveness and eosinophil infiltration.