摘要
对以焦化苯酚为原料,氨基甲酸铵为氨化剂合成4-羟基苯甘氨酸的体系进行了研究。考察了物料配比、反应温度、反应时间等主要因素对反应的影响,在原料配比为:1.4∶1,反应温度为50￣70℃,反应时间为8h,返入N2保护,得到的产品纯度>99%,反应易于控制,具有较高的应用价值。
A new method for synthesis of 4-hydroxyphenylglycine was developed by amination in the presence of carbamic ammonium. condition was as follows：the ratio of phenol and is 1.4：1 （mol） temperature 50-70℃ reaction time 8 h.The purity of 4-hydroxyphenylglycine reached 99%, and the reaction conditions were easily controlled, which made it more suitable for industrial process.
出处
《精细化工中间体》
CAS
2005年第4期20-21,共2页
Fine Chemical Intermediates
