卵巢早衰患者血清抑制素B水平的改变

Serum levels of inhibin B are altered in premature ovarian failure

目的探讨抑制素B(INHB)水平在卵巢早衰(POF)患者血清中的改变及其意义。方法采用双抗体夹心酶联免疫吸附技术(SandwichELISA),检测正常育龄妇女月经周期第3天和POF患者血清INHB水平,并将其与FSH、E2进行相关性比较。结果与正常育龄妇女(109.0±35.0)pg/ml比较,POF患者INHB水平(36.8±17.0)pg/ml明显降低,差别有极显著意义(P<0.0001),且INHB与FSH负相关(r=-0.644,P<0.001),与E2正相关(r=0.427,P<0.01)。结论INHB与POF的发生相关性显著,血清INHB可以作为早期预测POF的参考指标。

Objective： To explore the relationship between serum inhibin B and premature ovarian failure （POF） . Methods： Serum levels of inbibin B on cycle day 3 were determined by a solid quantitative sandwich enzyme immunoassay technique （Sandwich ELISA） both in POF group and in control （ womem without POF） , and relationship between inhibin B and FSH, relationship between inhibin B and E2 were analyzed, Results： Mean （ ± SD ） concentrations of inhibin B were lower （ P 〈 0. 0001 ） in POF （ 36. 8 ± 17.0 ） pg/ml than controis （ 109. 0 ± 35.0） pg/ml, In all women, nonparametric correlations analysis demonstrated that inhibin B serum levels were negatively correlated with FSH （ r = - 0. 644, P 〈 0. 001 ） and positively correlated with E2 （ r =0. 427, P 〈 0. O1 ） . Conclusion： Lower concentrations of inhibin B may be partly responsible to POF through a special way.