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依达拉奉治疗急性脑出血临床疗效观察

Clinical efficacy of edaravone on the treatment of acute cerebral hemorrhage
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摘要 目的观察依达拉奉对急性脑出血的治疗效果。方法将116例脑出血患者随机分为治疗组和对照组。治疗组在常规治疗的基础上,给予依达拉奉30mg加5%葡萄糖或生理盐水100ml静脉滴注,30分钟内滴完,每日2次,共19天。治疗组于治疗前及治疗后第19天分别进行神经功能缺损评分及疗效评定。结果治疗19天后,治疗组神经功能缺损评分为(9.6±6.3)分,明显低于对照组的(14.4±7.6)分(P<0.05);治疗组的显效率和有效率分别为48.3%和86.2%,显著高于对照组的20.1%和62.1%(P<0.05)。结论依达拉奉可促进脑出血患者的神经功能康复。 Objective To evaluate the efficacy of edaravone on the treatment of acute cerebral hemorrhage, Methods 116 cases were divided into treatment group and control group randomly. Neurological functional feficit scores and the efficacy was recorded. Results After 19days treatment, the neurological functional deficit scores of treated group were 9.6±6.3, whereas those of the control group were 14.4±7.6. There was significant difference between rate(treated group:48.3% ;control group: 20.1% ; P〈0.05). Conclusion Edaravone can accelerate the recovery of neural function after cerebral hemorrhage.
出处 《宁夏医学杂志》 CAS 2005年第9期616-617,共2页 Ningxia Medical Journal
关键词 脑出血 依达拉奉 临床疗效 Cerebral hemorrhage Edaravone Efficacy/treatment
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参考文献8

  • 1任泽光,吴建中,尹可.高血压脑出血后脑血流及自由基变化规律及其与脑水肿的关系[J].中华神经外科杂志,1995,11(4):209-212. 被引量:90
  • 2Dorsch NW.Haemorrhagic stoke.Intracerebral and subarachnoid haemorrhage[J].Aust Fam Physician,1997,26:1145-1150.
  • 3Matsuo Y,Kihara T,Ikeda M,et al.Role of neutrophils in radical production during ischemia and reperfusion of the rat brain:effect of neutrophil depletion onextracellular ascorbyl radical formation[J].J Cereb Blood Flow Metab,1995,5:941-947.
  • 4Halliwell B.Reactive oxygen species and the central nervous system[J].J Neurochem,1992,59:1609-1623.
  • 5Martz D,Beer M,Betz AL.Dimethylthiourea reduces is chemic brain edema without effecting cerebral blood flow[J].J Cereb Blood Flow Metab,1990,10:352-357.
  • 6刘庆新,张苏明.急性脑出血继发缺血半暗带的研究进展[J].国外医学(脑血管疾病分册),2002,10(3):191-194. 被引量:118
  • 7Watanabe T,Egawa M.Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade[J].J Pharmacol Exp Ther,1994,271:1624-1629.
  • 8Peeling J,Yan HJ,Chen SG,et al.Protective effect of free radical inhibitors in intracerebral hemorrhage in rat[J].Brain Res,1998,795:63-70.

二级参考文献26

  • 1任泽光,中华神经外科杂志,1993年,9卷,205页
  • 2黄如训,中国神经精神疾病杂志,1990年,16卷,136页
  • 3Chan P H,Neurology,1984年,34卷,315页
  • 4Carhuapoma JR, Wang PY, Beauchamp NJ, et a1. Diffusion weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage. Stroke, 2000,31(3): 726-732.
  • 5Michael N, Louis D, Admas RE, et al.Cerebral blood flow is symmetricaly reduced in patients with intracerebral hemorrhage. Neurology, 1998, 50: A338.
  • 6Xue M, Del-Bigio MR. Intracortical hemorrhage injury in rats: relationship between blood fractions and brain cell death. Stroke, 2000,31(7): 1721-1727.
  • 7Peeling J, Yan HJ, Corbett D, et al. Effect of FK-506 on inflammation and behavioral outcome following intracerebral hemorrhage in rat. Exp Neurol, 2001, 167(2): 341-347.
  • 8Heiss WD, Kracht LW, Thicl A, et al. Penumbral probability thresholds of cortical flumazenil binding and bbod flow predicting tissue outcome in patients with cerebral ischaemia. Brain, 2001, 124: 20-29.
  • 9Mendebw AD. Mechanisms of ischemic brain damage with intracerebral hemorrhage. Stroke, 1993, 24:115-119.
  • 10Yang GY, Betz AL, Chenevert TL, et al. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg, 1994, 81 (1):93-102.

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