摘要
目的：探讨在EAE大鼠发病过程中，雷公藤内酯醇及雷公藤内脂醇与地塞米松的联合使用对发病进程、临床评分的影响。方法：将Wistar种健康、雌性大鼠左后肢足垫皮下注射CFA-GPSCH抗原乳剂0.4ml/只，右足背皮下或皮内注射PT0.05ml/只（含5.0×10^9个菌体）。设免疫当日为零天，每天称重，采用双盲法两人进行临床症状评分。结果：免疫后15d，取临床评分相同者的归为一个级别，共获得3个级别的动物，每个级别的动物分成三组分别给予生理盐水、雷公藤内脂醇、雷公藤内脂醇和地塞米松的共同使用。结论，雷公藤组和联合组的发病进程缩短，临床评分明显下降。
objective： to observe the symotom and process of clinical in EAE wistar rat used the triptolide and triptolide co - treatment with dexamethasone. Methods healthy, female wintar rats are injected the 0.4ml CFA-GPSCH/rat and 0.05mlPT/rat. The injection day is zero, everyday the rat is weighted, the doube - blind method is used. Results Post inoculation 15, the same symptoms is the same level, there are three, the same level is divided three group given by normal saline, triptolide and the mixture of triptolide and dexamethasone. Condutions the symptom and process of triptolide group and the co-treatment group are cut dowm.
