急性肾小球肾炎患儿IgG亚类与尿系列酶、尿4项微量蛋白的相关性

Clinical significance of IgG subclass and relationship with urine enzyme series and four microalbumen in acute glumerulonephritis

目的探讨IgG亚类在急性肾小球肾炎(简称急性肾炎)发生中作用及其在临床诊断中的意义。方法采用酶联免疫吸附测定法检测26例急性肾炎患儿及20例正常儿童的IgG亚类水平,采用免疫散射速率比浊法测定尿4项微量蛋白,采用碱性苦味酸速率法测定尿系列酶,采用多元线性回归法分析相关性。结果26例急性肾炎患儿IgG1和IgG2明显低于正常对照组,(3.35±1.20)g/L和(0.70±0.61)g/Lvs(5.61±2.02)g/L和(2.35±1.02)g/L(P<0.01),IgG3高于正常对照组(0.68±0.62)g/L和(0.41±0.16)g/L(P<0.05);急性肾炎组IgG1与尿微量白蛋白(MA)呈明显负相关性,标化后的回归系数为-0.857,P<0.05,IgG2与γ谷氨酰转移酶(GGT)呈负相关性,标化后的回归系数为-0.669,P<0.05。结论IgG亚类失调,尤其是IgG1、IgG2下降参与了肾炎的发病,与GGT、MA呈明显负相关,可反映疾病的严重程度,在临床诊断中具有有一定的价值。

Objective To explore clinical significance of IgG subclass and the relationship with urine enzyme series and four microalbumen in acute glumerulonephritis. Methods IgG subclass, urine enzyme series, microalbumen （MA） were detected between 26 cases with acute glumerulonephritis and 20 controls of normal children. Results The levels of IgG1, IgG2 in acute glumerulonephritis were significantly decreased compared with those of the normal controls,（3.35±1.20） g/L and （0.70±0.61） g/L vs （5.61±2.02） g/L and （2.35±1.02） g/L（P 〈0.01）. The level of IgG3 was increased over that of control group （0.68±0.62） g/L vs （0.41±0.16） g/L（ P ±0.05）. In addition,the levels of IgG1 were negative related to MA in acute glumerulonephritis, standardized coefficients was -0. 857, P 〈 0.05; the levels of IgG2 were negative related to gamma glutamyl transferase （GGT）, standardized coefficients was -0. 669, P 〈0.05. Conclusion IgG1 ,IgG2 subclass decreasing and IgG3 increasing may participate in the pathogenesis of acute glumerulonephritis,the levels of IgG1 and IgG2 were negative related to MA and GGT,so IgG1 and IgG2 may be correlated with the seriousness of acute glumerulonephritis.