三联疗法治疗幽门螺杆菌感染的疗效

Curative Effects of Triple Therapy in Children with Helicobacter Pyl ori Infection

目的用克拉霉素加阿莫西林及奥美拉唑与标准三联疗法(阿莫西林+枸橼酸铋+甲硝唑)对照,三种方案、三种疗程治疗Hp感染儿童,评价其疗效.方法经胃镜检查确诊为慢性胃炎或十二指肠溃疡且Hp呈阳性的患儿204例随机分组,A组治疗方案为阿莫西林50 mg/(kg·d),枸橼酸铋7～8 mg/(kg·d),甲硝唑15～20 mg/(kg·d),疗程6周.B组用药与A组相同,疗程为2周.C组为克拉霉素15 mg/(kg·d),奥美拉唑0.8 mg/(kg·d),阿莫西林50mg/(kg·d),疗程2周.结果A组Hp根除率73.4%,B组Hp根除率75%,C组Hp根除率92%,B组和C组比较有显著性差异(P＜0.05).结论以克拉霉素、奥美拉唑、阿莫西林三联治疗儿童Hp感染,具有疗程短、疗效高、耐药少、依从性好、Hp根除率高等优点.

Objective To study the effects of new triple therapy with clarithromycin plus amoxicillin and omeperazole combined into 3 therapeutic there, pies, and 3 therapeutic courses to treat children with helicobacter pyloric（Hp） infection. Methods Two hundred and four patients who were diagnosed by gastroscopy as Hp - related gastroentestinal diseases and divided into 3 groups, randomly. Group A was treated with amoxieillin 50mg/（kg·d） ＋ bismuth citrate 7 - 8 mg/（ kg·d） ＋ metronidzole 15 - 20mg/（ kg·d ） for six weeks;group B took the same drugs but for two weeks;group C was treated with clarithromycin 15 mg/（kg·d） ＋ omeperazole 0.8 mg/ （kg·d） ＋ amoxicillin 50 mg/（kg·d） for 2 weeks. Results The rates of eradicate of Hp： group A 73.4%, group B 75%, group C 92 %. The differences between group B and group C were very significant. Conclusion Triple therapy is more effective, less duration, well tolerated, less resistant, with higher rate of eradication.