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前景诱人的RNA干扰技术

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摘要 癌症、肥胖症及心脏病等人类最大的杀手也许很快就可以用一种革命性的基因疗法来进行治疗,让造成这些疾病的基因安静下来。据美国和德国科学家最近发表在《自然》周刊上的报告说,这一技术是在近期RNA干扰技术(RNAi)取得重大突破的基础上发展起来的,首先被用于降低胆固醇。以前人们一直认为RNA会执行细胞中DNA的命令,但在过去10年里,
作者 刘剑
出处 《中学生物教学》 2005年第9期10-11,共2页 Teaching of Middle School Biology
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  • 1Knight SW,Baas BL.Arole for the RNase Ⅲ enzyTne DCR-1 in RNA interference and germ line development in Caenorhabditis elegans[].Science.2001
  • 2Rossi JJ.Medicine:a cholesterol connection in RNAi[].Nature.2004
  • 3Nishikura K.A short primer on RNAi:RNA-directed RNA polymerase acts as a key catalyst[].Cell.2001
  • 4Carthew RW.Gene silencing by double-stranded RNA[].Current Opinion in Cell Biology.2001
  • 5Dalmay T,Hamilton A,Rudd S,et al.An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus[].Cell.2000
  • 6Choisne N,Martin-Canadell A,Small Ⅰ.Transactivation of a target gene using a suppressor tRNA in transgenic tobacco plants[].Plant Journal The.1997
  • 7Marx J.Interfering with gene expression[].Science.2000
  • 8Fire A,Xu S,Montgomery MK,et al.Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans[].Nature.1998
  • 9Hammond SM,Caudy AA,Hannon GJ.Post-transcriptional gene silencing by double-stranded RNA[].Nature Reviews Genetics.2001
  • 10Kennerdell JR,Carthew RW.Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway[].Cell.1998

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