摘要
目的通过对贲门癌手术中各项因素的分析,探讨影响食管贲门癌术后生存时间的相关因素。方法回顾性分析1987年6月至1999年5月在本院手术的101例贲门癌患者。单因素分析采用Kruskal-Wallis检验,Cox模型进行多因素分析。结果淋巴结转移站、nm23基因的表达率和年龄与贲门癌的预后存在显著相关性。CD44、ras、p53表达与淋巴结的转移也存在显著的相关性。结论淋巴结转移站、nm23基因的表达可作为判定贲门癌手术预后独立指标。
Objective To find out the factors influencing survival time of gastric cardia cancer after operation through analysis of potential factors during operation. Method Follow-up study was taken among 101 patients with gastric cardia cancer from June 1987 to May 1999. Fifteen prognostic factors were analyzed： （1）Unvariate analysis： Kruskal-Wallistest for Kaplan-Meier survival curve; （2）Multivariate analysis：Cox propotional hazard model. Result Two factors： the lymph nodes metastases numbers and expression of the nm23 were proved to be relative to prognosis of gastric cardia cancer. Conclusion Examination of lymph nodes metastases and expression of the nm23 can be used to predict the prognosis of gastric cardia cancer after operation.
出处
《循证医学》
CSCD
2005年第4期222-224,共3页
The Journal of Evidence-Based Medicine
关键词
胃肿瘤
贲门
预后因素
COX比例风险模型
gastric neoplasms
cardia
survival factor
Cox proportional hazard model
