急性白血病患者化疗方案中应用力素对化疗药物急性心脏毒性的影响

Effect of calcium dibutyryladenosione cyclophosphate on chemotherapeutic toxicity in acute leukemia

目的:观察急性白血病化疗患者应用力素(二丁酰环磷腺苷钙)对化疗药物急性心脏毒性的影响。方法:将初治急性白血病患者58例分成治疗组(n=28)和对照组(n=30)两组,治疗组在普通化疗方案的基础上加用力素治疗,对照组仅用普通化疗方案治疗,观察两组第二疗程化疗后心肌酶的变化、心力衰竭的发生情况、平均心率及心电图ST段的变化。结果:两组的心肌酶(磷酸肌酸激酶、乳酸脱氢酶及α羟丁酸脱氢酶)、平均心率、心电图ST段的下移的程度差异均有显著性(P<0.01或0.05);但两组的心力衰竭发生情况差异无显著性(P>0.05)。结论:力素能够减轻化疗药物对急性白血病化疗患者的急性心脏毒性。

Objective： To observe the effect of calcium dibutyryladenosine cyclophosphate （CDBAC） on chemotherapeutic toxicity in acute leukemia. Methods： Fifty-eight initial treatment patients with acute leukemia were divided into 2 groups： control group （n=30） treated with conventional chemotherapy regimen, and treatment group （n= 98） received chemotherapy and CDBAC. Myocardial enzyme, heart failure, average heart rate and ST segment were observed in two groups after two courses. Results： Except heart failure incidence, creatine phosphate kinase, lactate dehydrogenase and hydroxybutyrate dehydrogenase levels, average heart rate and ST segment descent were significantly lower in treatment group than that in control group （P〈0. 01～0.05）. Conclusion： CDBAC alleviates acute heart toxicity in patients with acute leukemia during chemotherapy.