女性不孕患者解脲支原体、人型支原体和抗子宫内膜抗体水平的检测

Genital tract infection of Ureaplasma urealyticum and Mycoplasma hominis and serum anti-endometrial antibody in infertile women

目的:研究女性不孕与解脲支原体(UU)、人型支原体(MH)感染和抗子宫内膜抗体(AEMAb)之间的关系。方法:采用培养法分别对139例原发性和167例继发性不孕患者的宫颈分泌物进行UU、MH检测;采用ELISA法检测血清中AEMAb。同时选择健康已孕妇女102人作为对照组。结果:原发性及继发性不孕组UU、MH感染率及AEMAb阳性率与对照组比较差异均有显著性(P<0.01);原发不孕组与继发不孕组UU、MH感染率、AEMAb阳性率相比差异无显著性(P>0.05);不孕组中支原体感染阳性患者AEMAb阳性率明显高于支原体阴性患者(P<0.01)。结论:女性不孕与生殖道支原体感染及免疫因素有关,且AEMAb的产生与支原体感染有关。

Objective： To study the relationship between Ureaplasma urealyticum （UU） and Mycoplasma hominis （MH） injection and anti-endometrial antibody （AEMAb）in infertile women. Methods：UU and MH in cervical secretions and serum AEMAb level in 139 wornen with primary infertility, 167 with secondary infertility and 102 controls were determined by culture and ELISA, respectively. Results：Positive rates of UU. MH and AEMAb in infertile group were significantly higher than that in control group （P〈0. 01）, but there were no ,statistical differences between primary and secondary infertility （P〉0. 05）. The detection rate of AEMAb in infertile patients with mycoplasma were superior to that without mycoplasma （P〈0. 01）.Conclusion： Genital tract infection of UU and MH and immunological factor could be related to female infertility, AEMAb formation may be induced by mycoplasma infection.