糖尿病慢性并发症患病率及其与血糖和血脂的关系

Study on the association of chronic complication incidence with plasma glucose and lipids in diabetic patients

目的探讨糖尿病慢性并发症患病率与血糖和血脂之间的关系。方法收集近5年收住我院的210例糖尿病患者的病历资料,分析慢性并发症的患病率及其与相关指标间的关系。结果210例糖尿病人中慢性并发症160例,发生率为76.2%,其中部分患者有两种或两种以上并发症。各并发症组的空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白Alc(GHbAlc)和甘油三酯(TG)值显著高于无并发症组(P<0.05),而总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)在并发症与无并发症组之间差异无显著性(P>0.05)。并发症患者的FPG和2hPG与TG之间有显著正相关性(P<0.01和P<0.05)。结论持续高水平FPG、2hPG、GHbAlc和TG可能是糖尿病慢性并发症发病的危险因素和预报因子,同时较高的血糖水平与TG增高密切相关。

Objective To explore the association of chronic complication incidence with changes of plasma glucose and lipids in diabetic patients. Methods 210 cases of hospitalized diabetes in recent 5 years were reviewed. The incidence of chronic complications and their relation with relative factors were analyzed. Results 160 cases of 210 had chronic complications and some patients had two or more complications. The incidence was 76. 2%. Fasting plasma glucose （FPG）, post 2 hours plasma glucose （2hPG）, GhbAlc and triglyceride （TG） in the patients with complication were much higher than those in the ones without complication （P〈0. 05）. But total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C） in the serum had no significant differences （P〉0. 05） between patients with without complication. There was a significant correlation of 2hPG and TG in patients with complication. Conclusion Much higher FPG, 2hPG, GhbAlc and TG were risk and predict factors raising chronic complications in diabetes, and there was a significant correlation between higher blood glucose and TG in diabetic patients with chronic complications as well.