膀胱癌患者血清、尿液中TGFβ1水平测定及临床意义

Measurement of serum and urine TGFβ1 level in bladder cancer patients and its clinical significance

目的:探讨膀胱移行细胞癌患者TGFβ1水平测定及其临床意义。方法:采用酶联免疫吸附法检测膀胱癌患者血清、尿液中TGFβ1浓度。结果:膀胱癌患者血清TGFβ1水平(72.64±14.31)ng/ml显著高于正常对照(62.07±11.36)ng/ml,随病理分期、分级提高和肿瘤进展,膀胱癌患者血清TGFβ1水平呈下降趋势。患者尿液TGFβ1浓度(803±552)pg/ml显著低于正常对照(2995±1891)pg/ml,不同病理分期、分级之间差异无显著性。结论:血清TGFβ1水平增高可能是膀胱癌患者免疫功能受损的原因;尿液TGFβ1浓度降低可能导致肿瘤细胞增殖加速,成为膀胱癌复发的危险因素。

Purpose：To study the role of TGFβ1 in the occurrence and developnment of bladder transitional cell earcinorna.Methods：To quantitatively measure the serum and urine TGFβ1 level in bladder eancer patients with ELISA technique.Results：The serum TGFβ1 level（72.64±14.31ng/ml）in bladder cancer patients was significantly higher than that in normal controls（62.07±11.36ng/ml）,wih the proigression in pathological stage.grade and tumor advancement,the serum TGFβ1 level in patients changed in a decreasing trend.The urine TGFβ1 level（803±552pg/ml）in patients was significantly lower than that in normal controls（2995±1891pg/ml）.The differences of urine TGFβ1 level in patients with defferent pathological stages and grades were not significant.Conelustions：The elevated serum TGFβ1 level in patients could lead to the acceleration of tumor cell proliferation and may be the risk factor for tumor recurrence.