摘要
基底细胞癌是最常见的皮肤恶性肿瘤之一。近几年的研究发现Hedgehog信号通路中Hedge-hog基因、Patched基因、Smoothened基因及Gli基因等的突变使Hedgehog信号通路目的基因GLI2、WNT、HIP等的持续激活在基底细胞癌的发生发展中起关键性作用,因而调节这个通路的活性对治疗基底细胞癌有重要的指导意义。
出处
《国外医学(皮肤性病学分册)》
2005年第5期320-322,共3页
Foreign Medical Sciences(Section of Dermatology and Venereology)
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同被引文献64
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1刘瑛,李承新,刘玉峰.皮肤鳞状细胞癌中Patched-1和Gli-1蛋白检测及mRNA表达的研究[J].中国皮肤性病学杂志,2006,20(8):463-465. 被引量:5
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引证文献6
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1刘瑛,李承新,刘玉峰.皮肤鳞状细胞癌中Patched-1和Gli-1蛋白检测及mRNA表达的研究[J].中国皮肤性病学杂志,2006,20(8):463-465. 被引量:5
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3白育萍,刘海燕,高滢,刘玉峰,李承新.皮肤鳞状细胞癌皮损和细胞系中Patched-1及Gli-1表达的检测[J].中国皮肤性病学杂志,2008,22(7):388-390. 被引量:2
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二级引证文献13
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1白育萍,刘海燕,高滢,刘玉峰,李承新.皮肤鳞状细胞癌组织和细胞系中Ptch-1及Gli-1表达的检测[J].第四军医大学学报,2008,29(7):642-644.
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2刘海燕,周扬,白育萍,刘玉峰,李承新.KAAD-环巴胺抑制Hedgehog信号通路对人鳞状细胞癌细胞株A431生长及凋亡的影响[J].中华皮肤科杂志,2008,41(6):387-390.
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6李萍,冯世军,朱文胜,艾东方,杨秀芳.Patched-1和Gli-1在尖锐湿疣皮损中的表达及意义[J].山东医药,2012,52(36):88-89. 被引量:2
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