正常灌注压突破影响因素及动物模型的初步探讨

Affected factors of normal perfusion presure breakthrough and establishment of animal model

本研究于３６只健康Ｗｉｓｔａｒ鼠颈部复制动静脉瘘（ＡＶＦ），应用伊文氏蓝渗漏染色及血流动力学测定等手段，探索正常灌注压突破动物模型的形成条件，并对“高灌注突破”现象的影响因素──高血压、巴比妥酸盐药物进行了相关研究。其结果为现有理论提供了更多的实验依据，对临床的诊治作出了有益的启示，并奠定了进一步理论研究的开端。

This experiment were based on 36 purebred Wistar rats,that cervical arteriovenous fistulae were made by vascular anastomosis. Evan blue staining and hemogynamic monitoring were applied.The correlation between the hypertension and barbiturates and the occurence of hyperperfusion breakthrough phenomenon were analyzed. The result of experiment provided some evidences to the existing theory, and it may be useful for clinical diagnosis and treatmenet. It need continue to study.