矽宁、汉防己甲素及磷酸羟基喹哌对实验性矽肺疗效的比较

Therapeutic effect of Xinin, Tetrandrine and Hydroxypiperaquinine phosphate on experimental silicosis

对矽宁、汉防己甲素(汉甲)和磷酸羟基喹哌在等毒条件下进行了大鼠实验性矽肺的疗效研究,结果表明,治疗3个月后全肺湿、干重及肺胶原蛋白含量明显低于矽肺对照组,差别显著,但治疗组之间无明显差异;病理形态显示矽宁和汉甲组对矽肺纤维化有更明显的抑制作用,病灶间和肺泡腔内具有大量泡沫样细胞浸润。治疗组的肺巨噬细胞内均有细小的棕褐色颗粒。矽宁治疗组血清中SOD和铜蓝蛋白的含量明显低于其它治疗组。

A comparative study of Xinin, Tetrandrine and Hydroxypiperaquinine phosphate on experimental silicotic rats was carried out. Xinin,Tetrandrine or Hydroxypiperaquinine phosphate were given to experimental silicotic rats orally at the dosages of 39mg/kg, 35mg/kg and 18mg/kg, five times a week for 3 months respectively. These dosages were one thirtieth of the median lethal doses of these three medicines. The results showed that the dry weight and collagen contents of rat lungs of the treatment groups were much lower than that of the silicotic control group (P<0.05). But there were no differences of collagen contents in the rat lung among Xinin, Hydroxypiperaquinine phosphate and Tetrandrine groups. Large formlike cells aggregating in nodules with a slight fibrosis were the main pathological changes in Xinin and Tetrandrine groups. The value of SOD and ceruloplasmin contents in Xinin group were significantly decreased than those of the silicotic control and other treatment groups.