巴曲酶对短暂性脑缺血发作患者血浆NSE、ET及TXB_2的影响及意义

The Dynamic Effect and Meaning of Batroxobin on the Levels of Neuron-Specific Enolase, Endothelin and Thromboxane B_2 in Plasm of Patients with Transient Ischemic Attacks

目的:探讨巴曲酶对短暂性脑缺血发作(TIA)患者血浆特异性神经元烯醇化酶(NSE)及内皮素(ET)的影响及意义。方法:120例发病24h内颈内动脉系TIA患者,以发作持续时间和次数分为轻症组、重症组,每组各分为常规治疗组和巴曲酶治疗组,均于发病当天即给予治疗,并于发病24h,第3、7、14天测血浆NSE、ET、TXB2水平,同时比较其疗效。结果:TIA发生24h后即出现NSE、ET、TXB2水平升高,第3天升高更明显,至第7天起呈下降趋势,至第14天进一步下降。巴曲酶治疗组NSE、ET、TXB2水平较常规治疗组水平降低,轻症组低于重症组(P<0.05)。巴曲酶治疗组总有效率(79.00%)高于常规治疗组(25.00%),轻症组(巴曲酶组90.00%,常规组33.33%)有效率高于重症组(巴曲酶组66.67%,常规组16.67%)(P<0.05)。结论:巴曲酶可降低颈内动脉系TIA患者血浆NSE、ET、TXB2水平并能反映病情及预后。

Objective： To investigate the affection and meaning of batroxobin on the levels of neuron-specific enolase （NSE）,endothelin （ET） and thromboxane B2 （TXB2） in plasm of patients with transient ischemic attacks （TIAs）. Methods： 120 cases of TIAs （〈24 h from onset） were divided into the mild illness group and the severe illness group according to the times and duration of attack, then every group was divided into two groups which were gived routine treatment and routine treatment united by batroxobin respectively. The levels of NSE ,ET and TXB2 were measured on 24 h, 3 d, 7 d and 14 d from the onset and the curative effect was observed. Results： The curative rate of the group treated with batroxobin （79. 00% ） was higher than the group treated routinely（25.00% ） and the curative rate of the mild illness group （batroxobin group 90.00%, routine group 33.33% ） was higher than that of the severe illness group （batroxobin group 66. 67%, routine group 16. 67%） （P〈0. 05）. Simultaneously, the levels of NSE ,ET and TXB2 in the group treated with batroxobin were lower than the group treated routinely （P〈0. 05）. Condusion：atroxobin may be effective in treating TIAs and the change of the levels of NSE ,ET and TXB2 may reflect the state and prognosis of illness.