胆囊癌与女性激素关系的初步探讨

Estrogen and progesterone of gallbladder carcinoma

目的：探讨胆囊癌的发生、发展与女性激素的关系．方法：应用酶联亲和组织化学方法，对２８例胆囊癌组织及２０例慢性胆囊炎组织进行雌激素受体（ＥＲ）及孕激素受体（ＰｇＲ）检测．结果：２８例胆囊癌组织中１２例显示女性激素阳性（４２．８５％），其中ＥＲ阳性１１例（３９．２８％），ＰｇＲ阳性３例（１０．７１％），ＥＲ及ＰｇＲ同时阳性２例（７．１４％）．２０例慢性胆囊炎组织中仅见２例呈ＥＲ弱阳性反应．此外，对胆囊癌的病理组织学类型与受体表达的关系进行了探讨．结论：胆囊癌中部分患者具有女性激素依赖性特点，其中尤以ＥＲ更为重要，ＥＲ在胆囊癌的发生、发展中具有重要的作用。

Objective: To study the effects of estrogen receptor (ER) and progesterone receptor (PgR) on development of gallbladder carcinoma. Methods: By means of enzyme linked histochemical technique, ER and PgR were measured in the tissues of 28 gallbladder carcinoma and 20 chronic cholecystitis. Results: Twelve in 28 gallbladder carcinoma had high expression of these two receptors, while there were only two cases of chronic cholecystitis having weak expression of ER. The positive rate of gallbladder carcinoma was 39.28% for ER, 10.71% for PgR, and 7.14% for both ER and PgR. In the mean time we also discussed the relation between the expression of ER and pathological morphology. Conclusion: The over expression of ER may play an important role in the onset and development of gallbladder carcinoma, and provide a theoretic basis for its clinical diagnosis, treatment and pregnosis.