母传甲型肝炎抗体衰减过程分析

WANING PROCESS ANALYSES OF MATERNAL ANTI-HAV ANTIBODY AMONG≤24 MONTHS INFANTS.

目的:了解母传甲型肝炎抗体衰减过程,为制定科学的免疫程序提供依据。方法:采集310名0～24月龄健康儿童血清,测定抗HAV总抗体,分析不同月龄组的抗体水平。结果:<1个月龄组甲肝抗体阳性率和几何平均滴度(GMT)均最高,分别为98.04%和2451.55mIU/ml,之后逐渐下降,12个月～组降至最低,12个月～和18～24个月龄组间甲肝抗体阳性率和GMT差异均无统计学意义。结论:12～24月龄应为甲肝疫苗免疫的最佳时期。

Objective： To explore the level of passively transferred matemal antibody to hepatitis A virus in ≤ 24 months infants.Metthods： 310 sera of healthy children （0 - 24 months old） were collected. Total anti-HAV antibody were assayed by ELISA, then the antibody level were compared and analyzed among different months groups. Results： There were very high maternal antibody against HAV, and the highest positive rate and GMT was 98.04% and 2451.55 mIU/ml respectively within one-month-age children. Then HAV antibody lowered to the minimum in 12 months group. There was no significant difference among 12 - 18 and 18 - 24 months groups for HAV sera positive rate and GMT. Condusion： The optimum time for HVA immunization is 12 - 24 months of age.