病原性大肠埃希菌腹泻的实验与临床研究

EXPERIMENTAL AND CLINICAL STUDY ON DIARRHOEA CAUSED BY PATHOGENIC E.COLI

目的:探索病原性大肠埃希菌腹泻的实验与临床关系。方法:采集临床门诊急性腹泻患者粪便,进行ETEC,EPEC,EIEC等病原菌常规检测,并收集患者病史临床表现。结果:从839例腹泻患者中检出病原性大肠埃希菌235株,检出率为28.01%;其中ETEC118株(14.06%),。EPEC93株(11.08%),EIEC24株(2.86%),占病原菌检出的61.84%。对214印例病原性大肠埃希菌腹泻患者病史临床表现分析,3种病原性大肠埃希菌引起腹泻,临床表现不尽相同。病原性大肠埃希菌间或同其它病原菌混合感染43例13.5%),其临床表现,同单一病原菌感染比较,差异无显著性。结论:病原性大肠埃希菌引起腹泻的临床表现差异甚大;实验室病原检测是重要依据;对腹泻病因诊断有重要参考意义。

Objective： To study the relationship between experimence and chnic of diarrhoea caused by pathogenic E. coli.Methods： 839 fecal specimens of acute diarrhoea patients were collected to detect ETEC, EIEC and other bacleria pathogens.The clinical presentations and the disease histories of the patients were also collected.Results： 235 strains of pathogenic E. coli were detected from 839 diarrhoeal patients, the detection rate was 28.01%, among which there were 118 stains of ETEC （14.06%）, 93 strains of EPEC （11.08%）, 24 strains of EIEC （2.86 % ） . The detected pathogenic E. coil counted for 61.84 % of detected bacteria causing diarrhoea. The clinical presentations were not all the same among diarrhoea patidents. There were 43 cases multiplely infected by the different pathogenic E. coil and/or other pathogenic bacteria. There was no significant clinical difference between the multiple infection and the single infection caused pathogenic bacteria. Conclusions： The pathogenesis of diarrhoea caused by pathogenic E. coil was very complex. The clinical presentations were different although the most reliable diagnosis of the cause of diarrhoea was the detection of the pathogens in laboratory, but the clinical presentations and disease history would be also helpful.