成都地区SD大鼠参考值范围的探讨(一)——体重和主要脏器正常参考值

PRELIMINARY INVESTIGATION FOR THE REFERENCE RANGE OF SD RATS IN CHENGDU REGION-BODY WEIGHT PARAMETER AND ORGANS' VALUES

目的:建立本室实验动物正常生理数据的历史性对照,是评价毒理学重要的基础工作之一。方法:收集整理了本实验室近1年来30d喂养试验320只SD大鼠的相关数据,用PEMS软件统计了体重、进食量、食物利用率和脏器系数等的均值和95%的上下限值。结果:在本室饲养条件下,离乳鼠喂养30d后,雌雄鼠体重分别为185.0g±12.0g和232.1g±19.1g,雌雄鼠在30d内总增重分别为158.7g±19.8g,114.6±11.2g;雌雄鼠的食物利用率分别为36.6%±9.8和28.6%±6.2,体重及脏器等指标在雌雄鼠间均存在明显差异(P<0.05)。结论:该参考值在评价毒理学工作具有实际应用价值。

Objective： To establish baseline data for the laboratory and supply the reference for establishing the country standard,Methods： The data of thirty days feeding study in SD rats was collected from our laboratory and processed statistically with PEM medical statistics software. Results： Body weights of the rats for male was 232 ± 19.1 g （ n = 130） and for famale was 185 ± 12.09 g （ n = 160） . Data listed include the mean and the standard deviation of body weight parameters and organs＇ values. Comparison between male rats and females rats was analvzed.Conclusion： Tiffs reference range is valuable in practice.