O型孕妇血清中IgG抗体效价与新生儿溶血病的关系

RELATIONSHIP BETWEEN THE VALENCE OF ANTIBODY OF PREGNANT WOMAN WITH BLOOD TYPE O IN SERUM AND HEMOLYTIC DISEASE OF NEWBORN.

目的:探讨O型孕妇血型抗体效价与新生儿溶血病之间的关系。方法:我院近3年间共有夫妇ABO血型不合731例,对其进行ABO-HDN血清学检查,观察高效价IgG抗A(B)对ABO-HDN的影响。结果:当孕妇血清抗体效价为1:64、1:128、1:256和≥1:512时,新生儿ABO溶血病的发病率分别为12.5%、21.7%、33.3%和51.6%。结论:随着孕妇IgG抗体效价的增高,新生儿ABO溶血病的发病率也随之升高,需采用相应的治疗措施。

Objective： To explore the relationship between the valence of antibody of pregnant woman with blood type O in serum and Hemolytic Disease of Newborn （HDN） .Methods： 731 couples were detected in order to know whether the blood type of mothers and newhorns conformed to each other during three years. The newborns with jaundice whose mothers＇ valence of antibodies were higher than 1 ： 64 were measured by the test of ABO and Hemolytic Disease of Newborn （ABO - HDN） in the sera, and were observed whether the high valence of antibody IgG had effects on ABO - HDN.Results： When the valence of antibody was 1 ： 64, 1 ： 128, 1 ： 256 and more than 1：512 the incidence of HDN was 12.5%, 21.7%, 33.3% and 51.6% respectively.Conclusion： The more the valence of antibody inthe serum with pregnant woman, the higher the incidence of HDN was, so it was necessary to take appropriate treatment.