核辅激活因子PGC-1表达的分子调控机制

Molecular Mechanisms in Regulation of Nuclear Coactivator PGC-1 Expression

过氧化物酶体增殖物激活受体γ辅激活因子1(peroxisomeproliferatoractivatedreceptorγcoactivator1,PGC1)是一种多功能的转录调节因子,其广泛参与线粒体生物合成及能量代谢、糖脂代谢等多条代谢通路调节的特点预示PGC1在现代医学中可能极具应用潜力.其表达量的降低或上调,对于生物体的代谢调节均具有相当的生理或病理意义.本文从转录水平和翻译后水平综述了调控PGC1表达的具体分子机制,重点对转录水平调控PGC1表达的3条信号通路的研究进展及生物学意义进行了探讨.对PGC1表达的分子调控机制中所蕴含的药物靶点应用前景进行了初步展望.

Peroxisome proliferators-activated receptor-γ coactivator-1 （PGC-1） is a versatile transcriptional regulator. Since PGC-1 is characteristically involved in the regulation of several crucial cellular pathways including mitochondrial biogenesis, gluconeogenesis, fatty acid oxidation and so forth, the coactivator may play potential role in the applications in modem medicine. Both down-regulate and up-regulate affect metabolism markably, which has considerable significance physiologically or pathologically. On the transcription and posttranslation level respectively, this review focuses on the detailed molecular mechanisms in the regulation of PGC-1. The advances in the three signaling pathways on the transcription level have been especially discussed here. Those molecular pathways and the prospect of PGC-1 as a potential molecular drug target has been tentatively commented also.