循证医学方法研究氟西汀与帕罗西汀治疗抑郁症的成本-效果

Cost-effectiveness Analysis on Fluoxetine and Paroxetine in the Treatment of Depressive Disorder by Evidence-based Medicine Method

目的:评价氟西汀与帕罗西汀治疗抑郁症的成本-效果。方法:采用循证医学方法收集氟西汀与帕罗西汀治疗抑郁症的临床资料,应用药物经济学的成本-效果分析法进行分析。结果:氟西汀与帕罗西汀治疗抑郁症的治愈率分别为36.30%、58.73%;成本-效果比分别为14.13、9.73;后者相对于前者的增量成本-效果比为2.60。结论:帕罗西汀治疗抑郁症的成本-效果优于氟西汀。

OBJECTIVE： To evaluate the cost - effectiveness of fluxetine and paroxetine in the treatment of depressive disorders. METHODS： The clinical data of fluxetine and paroxetine in the treatment of depressive disorders were collected by evidence - based medicine method and which were evaluated by cost - effectiveness analysis in pharmacoeconomics. RESULTS： The cure rates of fluxetine and paroxetine in the treatment of depressive disorders were 36.30% and 58.73%, respectively, and the cost- effectiveness ratios of which were 14.13 and 9.73, respectively. The incremental cost- effectiveness ratio of the latter vs. the former was 2.60. CONCLUSION： The cost - effectiveness of paroxetine is superior to fluxetine in the treatment of deoressive disorders.