丙氨酰谷氨酰胺双肽在胃肠道术后应用的安全性和有效性观察

Observation on the Safety and Efficacy of Alanyl-glutamine Dipeptide in Patients after Gastrointestinal Operation

目的:观察胃肠道术后患者在经周围静脉全肠外营养(TPN)中应用丙氨酰谷氨酰胺双肽的安全性和有效性。方法:64例胃肠道手术患者随机均分为常规TPN组(对照组)和TPN+丙氨酰谷氨酰胺双肽组(治疗组),所有患者均于术后第1d～第7d给予相应药物治疗。结果:术后第8d血清白蛋白、前白蛋白2组均有回升,但对照组回升较慢,2组间比较有显著性差异(P<0.05);术后第8d治疗组氮平衡明显优于对照组(P<0.01);术后感染发生率治疗组显著低于对照组(P<0.01);术后平均住院时间治疗组短于对照组(P<0.05)。结论:丙氨酰谷氨酰胺双肽在胃肠道术后经周围静脉TPN应用安全、有效。

OBJECTIVE： To investigate the safety and efficacy of alanyl - glutamine dipeptide administered via peripheral vein total parenteral nutrition（TPN） in patients after gastrointestinal operation. METHODS： 64 cases after gastrointestinal operations were randomly divided into routine TPN group（control group） and TPN plus alanyl- glutamine dipeptlde group （therapeautic group）, all of which were treated with the corresponding medicines from the first day to the 7th day after operation. RESULTS： The levels of both seralbumin and prealbumin rebounded on the 8th day after operation with those of the control group rebound more slowly, significant differences were noted between the 2 groups（P 〈 0. 05） ;Nitrogen balance in the therapeautic group was significantly better than the control group on the 8th day after operation（P 〈 0.01）;The incidences for postoperative infection complications in the therapeautic group was lower than the control group （P〈0. 01）; the average hospital stay for the therapeautic group was shorter than the control group （P 〈0.05）.CONCLUSION： It is safe and effective to use alanyl- glutamine dipeptide via peripheral vein TPN in patients after gastrointestinal operation.