5种中药煎剂与颗粒剂对临床分离菌株的体外抑菌作用比较

Comparison of in Vitro Bacteriostatic Action of5Traditional Chinese Medicine Apozems&Granules against Clinical Isolated Bacterial Strains

目的:探讨中药煎剂与颗粒剂的生物等效性,为临床合理用药提供依据。方法:采用M-H琼脂稀释法,测定黄连、黄芩、五倍子、五味子和黄柏煎剂与颗粒剂对224株临床分离菌株的MIC50、MIC90、MIC、MBC,以比较其抑菌作用。结果:5种中药煎剂与颗粒剂都显示出不同程度的抑菌作用,以五倍子煎剂抑菌作用最强。结论:5种中药煎剂抑菌作用比相应颗粒剂抑菌作用强。

OBJECTIVE： To discuss the bioequiavailability of traditional Chinese medicine apozems and granules and to provide references for the rational drug use in the clinic.METHODS：Coptidis rhizome,scutellaria,Chinese gall, fructus schizandrae,cortex phellodendri decotion and granules against The M IC50, MIC90, MIC and MBC of 224 strains of clinical isolated strains were determined by M- H agar dilution method and the hacteriostatic actions of which were compared .RESULTS： 5 traditional Chinese medicine apozems and granules showed different degree of antibacterial actions, with the Chinese gall being the most potent.CONCLUSION：The apozems showed stronger antibacterial actions than the granules among the 5 traditional Chinese medicines.