摘要
通过同源重组将外源基因定点整合入靶细胞基因组上某一确定位点的基因打靶技术,已经成为哺乳动物遗传学领域的重要工具。本文拟针对胚胎干细胞和体细胞的基因打靶的原理、技术路线及基因打靶技术的发展和应用作一综述。
出处
《国外医学（遗传学分册）》
2005年第4期193-195,共3页
Foreign Medical Sciences(Section of Genetics )
基金
国家重点基础研究发展规划项目(No.2001CB509904)
上海市科委发展基金项目(No.010J14003)
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