重度妊娠肝内胆汁淤积症与胎儿生长受限的关系

Relationship between severe intrahepatic cholestasis of pregnancy and petal growth retardation

目的探讨重度妊娠肝内胆汁淤积症(ICP)与胎儿生长受限(FGR)的关系。方法回顾性分析48例重度ICP患者(ICP组)与对照组妊娠结局、新生儿体重、FGR发生率及ICP新生儿体重与胆汁酸、肝功能的关系。结果ICP组早产、羊水粪染、A pgar评分<7分(1分钟)的发生率与对照组比较差异有统计学意义(P<0.01)。ICP组新生儿平均体重为(3029.1±1042.5)g,FGR的发生率为6.3%,与正常组相比差异无统计学意义。多元线性回归分析,ICP组新生儿体重与胆汁酸、肝功能无明显线性关系。结论ICP与胎儿生长受限之间无相关性。

Objective To study the relationship between severe intrahepatic cholestasis of pregnancy （ICP） and fetal growth retardation （FGR）. Methods The data of 48 patients with severe ICP and the other 48 normal pregnant women as controls were retrospectively analysed. The weight of newborns,serum hilirubin,and liver function were comparatively studied to demonstrate the relationship between the weight of newborns and serum bilirubin or liver function. Results The occurrence of preterm birth,meconium in amnion,and neonatal Apgar score were lower in ICP group than controls. The mean weight of newborns was 3029.1±1042.5g in ICP group and the prevalence of FGR was 6.3% which was similar to controls. There was no relationship between the weight of newborns and serum hiliruhin and liver function by multi-factor linear analysis. Conclusion There is no adverse effect of ICP on the fetal growth.