胞磷胆碱钠治疗突发性聋的临床观察

A clinical study on application of eitieoline sodium in treatment for sudden deafness

目的观察胞磷胆碱钠治疗突发性聋的临床疗效．方法将123例（168耳）突发性聋患者随机分成胞磷胆碱钠组（治疗组）63例（84耳）和对照组60例（84耳），对照组采用传统的ATP、辅酶A、复方丹参和高压氧等综合治疗，治疗组在对照组基础上加用胞磷胆碱钠。治疗前和治疗后每3天进行一次纯音听力测试。结果治疗组和对照组在治疗前平均听闽分别为72．80±28．36dBHL和70．2±36．62dBHL（P〉0．05）．治疗后治疗组平均听阂为40．12±18．68dBHL、听力平均提高31．67±16．56dBHL，对照组平均听阈为5926±30．27dBHL、听力平均提高20．98±17．23dBHL，两组经统计学处理，差异有显著性意义（P〈0．05）。结论胞磷胆碱钠治疗突发性耳聋疗效肯定，明显优于传统疗法；且价格便宜，无任何毒副作用，值得广大基层医院推广首选。

Objective To investigate the clinical effects of application of citicoline sodium on sudden deafuess . Methods 123 patients（ 168 ears） with sudden deafness were randomly divided into two groups： the citicoline sodium group or experimental group （ n = 63, 84 ears）, and the control group （ n = 60 84 ears）, the control group received traditional ATP, COA, salvia miltiorrhiza complex and hyperbaric oxygen therapy, the experimental group given citicoline sodium and traditional therapy. The hearing threshold of all the patients were measured before and after treatment every 3 days. Results The hearing threshold was 72.80 ± 28.36dBHL in experimental group and 70.20 ± 36.62dBHL in control group （ P 〉0.05） before treatment. After the treatment, the increase of hearing in the citicoline sodium group and the control group was 31.67 ± 16.56dBHL and 20.98 17.23dBHL , respectively. There was significant difference （ P 〈 0.05 ）. No serious adverse reaction was observed. Conclusion The citicoline sodium is effective for treatment of sudden deafness. And the citicoline sodium may contribute to the recovery of the patients with sudden deafness better than the traditional methods.