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过氧化物酶体增殖物激活受体α在脂肪性肝病发病机制中的作用 被引量：5

The role of PPAR alpha in the pathogenesis of fatty liver disease
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摘要 脂肪性肝病(fatty liver disease,FLD)具有多样病因和多种形态谱,包括单纯性脂肪肝、脂肪性肝炎、脂肪性肝纤维化,以及其进一步进展为肝硬化和肝细胞癌[1].根据病因FLD被分成两大类:酒精性脂肪性肝病(alcoholic fatty liver disease,AFLD)和非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD).
作者 徐磊 厉有名
机构地区 浙江大学医学院附属第一医院消化科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2005年第9期715-717,共3页 Chinese Journal of Hepatology
关键词 脂肪肝 过氧化物酶体类 非酒精性脂肪性肝病 过氧化物酶体增殖物激活受体Α 病发病机制 disease 脂肪性肝纤维化 liver 单纯性脂肪肝 脂肪性肝炎 Fatty liver Peroxisomes
分类号 R575.5 [医药卫生—消化系统] R734.2 [医药卫生—肿瘤]
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参考文献15

  • 1Zafrani ES. Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch, 2004, 444: 3-12.
  • 2Desvergne B, Wahli W. Peroxisome proliferator-activated receptors:nuclear control of metabolism. Endocr Rev, 1999, 20: 649-688.
  • 3Moras D, Gronemeyer H. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol, 1998, 10: 384-391.
  • 4Hashimoto T, Cook WS, Qi C, et al. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem, 2000, 275: 28918-28928.
  • 5Fischer M, You M, Matsumoto M, et al. Peroxisome proliferatoractivated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem, 2003, 278: 27997-28004.
  • 6Francis GA, Annicotte JS, Auwerx J. PPAR-alpha effects on the heart and other vascular tissues. Am J Physiol Heart Circ Physiol,2003, 285: H1-9.
  • 7Campbell FM, Kozak R, Wagner A, et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonylCoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem, 2002, 277: 4098-4103.
  • 8Lee GY, Kim NH, Zhao ZS, et al. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. Biochem J, 2004, 378(Pt 3): 983-990.
  • 9Galli A, Pinaire J, Fischer M, et al. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J Biol Chem, 2001,276: 68-75.
  • 10Koh EH, Kim MS, Park JY, et al. Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes, 2003,52: 2331-2337.

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中华肝脏病杂志
2005年 第9期

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