C反应蛋白与不同类型冠心病的相关性分析及药物对其的干预

Analysis of the Corretation of C-reaction Protein with Different Kinds of Coronary Heart Diseases and Effect of Medicines on Them

目的:通过测定炎症反应标志物C反应蛋白(CRP)的浓度,探讨CRP与急性冠状动脉综合征(ACS)、稳定型心绞痛(SAP)的关系,以及阿斯匹林、普伐他汀对CRP的干预。方法:采用免疫比浊法测定不同类型冠心病CRP的浓度及观察用药后CRP的变化。结果:ACS组CRP显著高于对照组。急性心肌梗死(AMI)组CRP显著高于不稳定型心绞痛(UAP)、SAP及对照组,UAP组与SAP组、对照组相比CRP增高,差异有统计学意义。SAP组与对照组相比,CRP增高差异无统计学意义。阿斯匹林、普伐他汀联合应用可显著降低ACS组的CRP浓度。结论:急性冠状动脉综合征时CRP显著升高,表明在ACS过程中急性炎症反应起了重要作用,并在一定程度上反映心肌损伤及坏死的严重程度。他汀类药物及阿斯匹林能抑制炎症反应,对降低CRP浓度起到有效干预作用。

Objective： To investigate the relationship of C -reactive protein（CRP）, on inflammation marker,with acute coronary syndrome（ACS） and with stable angina pectoris（SAP） and the effects of aspirin and pravastatin on CRP by determining the concentration of CRP. Methods ： By the use of immune turbidimetric method, CRP level in different kinds of coronary heart diseases and effects of medicines（aspirin and pravastatin） on CRP were investigated. Results ：The CPR level of ACS is apparently higher than that of control group, The CRP level of acute myocardium ischemia（AMI） is apparently higher than that of group unstable angina pectoris （UAP） ,SAP and control group. In the CRP level among group UAP ,SAP and control,there is significant difference statistically. The CRP level shows no significant difference between SAP group and control group. The combination of aspirin and pravastatin can decrease apparently the CRP level of ACS group. Conclusion：When ACS occurs, the CRP level is increased apparently and showing that acute inflammation play an important role during the ACS and reflect the degree of myocardium injury and necrosis. Pravastatin and aspirin can inhibit inflammatary reaction and decrease CRP level.