扩张型心肌病免疫发病机制及治疗进展

Immunopathogenesis and Immune-associated Therapy of Dilated Cardiomyopathy

自身免疫为扩张型心肌病可能的发病机制之一。其中,体液自身免疫发挥了更重要的作用,一系列的自身抗体参与扩张型心肌病的发病。炎症细胞的活化和细胞毒性作用也参与了扩张型心肌病的发病。针对扩张型心肌病的免疫发病机制,可采用免疫吸附、血浆置换、免疫抑制治疗。

Autoimmunity is one of the probable pathogenesis of dilated cardiomyopathy, Humor autoimmunity plays a more important role in the pathogenesis of dilated cardiomyopathy by a series of autoantibodies. The activation of inflammatory cells and cytotoxic effect also participate the pathogenesis, Due to the immunopathogenesis of dilated cardiomyopathy, immunoadsorption, plasmapheresis and immunosuppressive therapy are adopted to treat this disease,