海洛因依赖者脑干听觉诱发电位研究

STUDY OF BRAINSTEM AUDITORY EVOKED POTENTIALS IN HEROIN ADDICTS

目的:探讨海洛因依赖者脑干听觉诱发电位的变化特点及其应用。方法:使用意大利百胜有限公司GalileoSirius全数字化32导脑诱发电位仪对32例海洛因依赖者和30例正常人脑干听觉诱发电位的变化进行对照分析。结果:海洛因依赖者波形稳定性较差,波Ⅰ、Ⅲ、Ⅴ出现率100%,以后依次为波Ⅳ、波Ⅱ、波Ⅵ、波Ⅶ,但与正常对照组比较,差异无显著性(P>0·05);波Ⅱ-波Ⅶ绝对潜伏期较正常人延长,其差异有显著性(P<0·05,P<0·01);波Ⅱ-波Ⅶ绝对波幅较正常人降低,其差异有显著性(P<0·05,P<0·01)。结论:海洛因依赖者的脑干听觉诱发电位具有波Ⅱ-波Ⅶ绝对潜伏期延长、绝对波幅降低的特点,这些特点除可作辅助诊断外,还能对早期预防依赖者的中枢神经系统并发症提供依据,同时建议对依赖者进行神经营养治疗。

Objective： To discuss the change and clinical usage of brainstem auditory evoked potentials （BAEP） in heroin addicts. Methods： The BAEP of 32 heroin addicts and 30 normal individuals were analyzed and compared in Galileo Sirius 32 channels digital evoked potential system. Results ： Compared with the normal group, the wave forms of heroin addicts were unstable, all indicating the occUrrence of Wave Ⅰ ,Ⅲ ,Ⅴ, and Wave Ⅳ, Ⅱ, Ⅵ,Ⅶ afterwads, showing no significant difference（P〉0.05） ; the BAEP in heroin addicts evoked delayed absolute latencies and decreased absolute amplitudes （Waves Ⅱ-Ⅶ）, showing significant difference （P〈0.05, P 〈0.01）. Conclusion：Heroin addicts had the characteristics of delayed absolute latencies and decreased absolute amplitudes （Waves Ⅱ-Ⅶ） , which might be used as auxiliary diagnostic criteria for heroin addicts, and provide data for early prevention of central neural system complications. Neural nutrition treatment is also suggested.