灵芝多糖对高脂血症大鼠血脂及脂质过氧化的影响

Effects of ganoderma lucidum polysaccharides on serum lipids andlipoperoxidation in ertperimental hyper lipidemic rats

目的:探索灵芝多糖对高脂血症大鼠血脂及脂质过氧化的影响。方法:50只大鼠随机分成5组:正常对照组、高血脂组和不同含量灵芝多糖组,除正常组外,其他组的大鼠采用高脂食物喂养1个月后,鼠尾采血测定血清总胆固醇(TC),甘油三脂(TG),高密度脂蛋白胆固醇(HDL-c)和低密度脂蛋白胆固醇(LDL-C),谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性及脂质过氧化物(LPO)。结果:灵芝多糖能明显降低TC,TG和LDL-C的浓度(P<0.01),能使HDL-C浓度升高(P<0.05),能明显提高血液GSH-Px和SOD酶活性(P<0.01),降低血液LPO的浓度(P<0.05)。结论:灵芝多糖能调节大鼠高脂血症的脂代谢和增强抗脂质过氧化的作用。

Objective： To investigate the effect of ganoderma lucidum polysaccharides on blood lipid and lipoperoxidation from the experimental hyperlipidemic rats. Method： 50 rats were randomly divided into normal group, hyperlipidemia control group, experimental group 1, 2 and 3 in which the rats were treated with ganoderma lucidum polysaccharides at dosages of 200 mg·kg^-1 and 400 mg·kg^-1 and 800mg·kg^-1 respectively. Apart from the rats in control group, all the rats in other groups were fed with high fat forage for 30 days. Tne blood was collected from the tails of rats for measuring the serum TC, TG, HDL-C, LDL-C, GSH-Px, SOD and LPO. Result： Ganoderma lucidum polysaccharides could significantly decrease the serum contents of TC, TG, LDL-c in the experimental hyperlipidemic rats（ P〈0.01 ）, and markedly increase the level of serum HDL-C（ P〈0.05）, Mean Level of blood LPO in the experimental groups treated by ganoderma lacidum pelysaccharides at different dosages were much lower than that in hyper lipidema group, and the GSH-Px and SOD activities of blood in the group of ganoderma were much higher than those in hyperlipidema group. Conclusion： Ganoderma can regulate lipid metabolism, enhance the antioxidation and reduce the lipid perexidation in the rats with hyperhpidemia.