早期帕金森病患者语言工作记忆特点

Verbal working memory impairment in early Parkinson’s disease patients

目的探讨帕金森病(PD)患者视觉语言工作记忆损害及其特点。方法仿制并修订了Smith工作记忆检查软件,对确诊的PD患者和对照组进行语言工作记忆检查。结果PD组(31例)语义性语言工作记忆检查的成绩(84.8%±9.1%)较对照组(30例)成绩(88.9%±7.2%)低,但差异无统计学意义(t=-1.935,P=0.058),PD组(28例)语音性语言工作记忆检查的成绩(83.6%±7.7%)较对照组(30例)成绩(88.4%±6.2%)显著下降,差异有统计学意义(t=-2.298,P=0.034)。右侧肢体起病的患者语义性(t=-2.075,P=0.044)和语音性(t=-2.593,P=0.013)语言工作记忆的成绩较左侧肢体起病的患者下降,差异有统计学意义。结论早期的PD患者存在语音性语言工作记忆的损害,语义性语言工作记忆相对保留。提示语音和语义性语言工作记忆加工应用不同的神经环路。

Objective To investigate the characteristics of verbal working memory impairment in early Pakinson＇ s disease （PD） patients and the underlying neuropsychological and patho-physiological mechanisms. Methods The Smith＇ s working memory software was modified and further developed as to studying the phonological and semantic verbal working memory deficits in early PD patients and normal controls. Results The correct rate of semantic verbal working memory test was lower in PD patients （n = 31, 84. 8% ± 9. 1% ） than in normal controls （ n = 30, 88.9% ±7.2% ）, but there was no significant difference between the two groups （ P = 0. 058 ）. The correct rate of phonological verbal working memory test was significantly lower （P 〈 0. 05 ） in PD patients（ n =28, 83. 6% ±7.7% ）than in normal controls （n = 30, 88. 4% ±6. 2% ）. Conclusion The present study suggests that the verbal working memory impairment might exist in early PD. The phonological verbal working memory might be impaired, and the semantic verbal working memory might be relatively spared. And the different verbal working memory subsystems should use different neurecircuits.