P_53蛋白在大肠癌组织中表达的预后价值

Prognostic value of p53 protein expression in colorectal carcinoma

用P_53单克隆抗体PAb1801对92例大肠癌组织中P_53蛋白表达进行检测,用时序检验方法分析P_53蛋白表达与大肠癌的预后关系。57.61%大肠癌有P_53蛋白表达,P_53蛋白表达与大肠癌Dukes分期相一致。生存资料分析显示p_53蛋白阳性大肠癌生存率低于P_53蛋白阴性大肠癌生存率。结果表明P_53蛋白在大肠癌组织中表达与大肠癌预后相关,是预后不良的标志。

p53 is an important suppressor gene that can suppress tumor cell growth. The muta- tions abrogate this suppressive effect. The p53 protein can be detected with immunohis- tochemical method when mutations result in abnormal p53 protein that accumulates in cells by virtue of an increased half-life. The expres- sion of p53 protein in 92 colorectal carcinoma patients was examined, using the monoclonal antibody PAb 1801. Correlation between p53 protein expression and prognosis in colorectal carcinoma was analyzed using log-rank test. The frequency of p53 protein expression was 57.61%, which was consistent with Dukes' classification. Analysis of survival data demon- strated that the survival rate of colorectal car- cinoma with p53 protein was lower than that of p53 protein negative group. It is concluded that the expression of p53 protein is in corre- lation with poor prognosis in colorectal carci- noma.